Physical causes of APSD changes in aerosols from OIPs and their impact on CI measurements

Abstract

The successful implementation of AIM and/or EDA principles to the in vitro assessment of inhalable aerosols emitted from OIPs requires the user of such methods to have a basic understanding of how these particles and/or droplets interact with the human respiratory tract (HRT) upon inhalation. Such processes are inextricably governed by the underlying physical processes associated with these semi-stable systems, and all of the changes influencing particle size affect the entire APSD. This chapter looks at both aspects in some detail, in particular paying attention to how small changes in APSD might be detected by full-resolution CI systems. The information presented herein is a prelude to Chap. 9, in which case studies are presented to demonstrate the sensitivity of EDA metrics to such changes.