Synthesis of Organometallic Oligonucleotides through Oximation with Metalated Benzaldehydes

Abstract

A phthaloyl-protected aminooxymethyl-C-2′-deoxyriboside building block has been prepared and incorporated in the middle of an oligodeoxyribonucleotide. Removal of the phthaloyl protection followed by on-support oximation with either mercurated or palladated benzaldehydes yielded oligonucleotides bearing the respective benzaldoxime metallacycles.