Novel biocompatible protein-oleic acid conjugate was prepared to form self-assembled nanoparticles (NP) when exposed to an aqueous medium. The conjugation of protein-fatty acid was confirmed using FTIR and NMR. The physicochemical properties of NP were characterized by the experimental conditions such as pH, temperature and the amount of protein/fatty acid. The self-assembled NP had a uniformly spherical shape with particle size (150-200 nm) and showed good physical stability. This NP had no any potential cellular toxicity. Paclitaxel was chosen as model drug for anti-cancer effect using self-assembled NP. Drug release was controlled over an extended period of time. Furthermore, surface-modified NP using folic acid showed a higher cancer-cell killing effect as compared with Taxol®. The in vivo pharmacokinetic parameters and biodistribution of the NP containing paclitaxel also indicated longer blood circulation. © 2013 IFMBE.
CITATION STYLE
Lee, B. J., & Tran, P. H. L. (2013). Protein-fatty acid conjugate for self-assembled nanoparticles in drug delivery. In IFMBE Proceedings (Vol. 40 IFMBE, pp. 301–303). https://doi.org/10.1007/978-3-642-32183-2_75
Mendeley helps you to discover research relevant for your work.