Assessment of risk factors associated with potential drug-drug interactions among patients suffering from chronic disorders

Abstract

Patients suffering from chronic diseases are more likely to experience pDDIs due to older age, prolonged treatment, severe illness and greater number of prescribed drugs. The objective of the current study was to assess the prevalence of pDDIs and risk factors associated with occurrence of pDDIs in chronic disease patients attending outpatient clinics for regular check-ups. Patients suffering from diabetes, chronic obstructive pulmonary disease (COPD), stroke and osteoporosis were included in the study. This study was a cross sectional, observational, prospective study that included 337 patients from outpatient clinics of respiratory ward, cardiac ward and orthopedic ward of Nishter Hospital Multan, Pakistan. The mean number of interactions per patient was 1.68. A greater risk for occurrence of pDDI was associated with older age ≥ 60 years (OR = 1.95, 95% CI = 1.44–2.37, p<0.001); polypharmacy (≥ 5 drugs) (OR = 3.74, 95% CI 2.32–4.54, p<0.001); overburden (OR = 2.23, 95% CI = 1.64–3.16, p<0.01); CCI score (OR = 1.28, 95% CI = 1.04–1.84, p<0.001); multiple prescribers to one patient (OR = 1.18, 95% CI = 1.06–1.41, p<0.01); and trainee practitioner (OR = 1.09, 95% CI = 1.01–1.28, p<0.01). Old age, polypharmacy, overburden healthcare system, higher comorbidity index, multiple prescribers to one patient and trainee practitioner were associated with increased risk of occurrence of pDDIs in chronic disease patients.