Development and formulation of phytoestrogen-rich supplement for women with polycystic ovary syndrome

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Abstract

Background: Polycystic ovary syndrome (PCOS) is an endocrine disorder with various health complications like menstrual irregularities, hirsutism, acne, obesity, and insulin resistance. It is becoming a prominent cause of infertility among women worldwide. A woman’s diet may ultimately affect her fertility, particularly ovulation. The assisted reproductive technologies for the treatment of infertility may cost high and have an adverse effect. To reduce the adverse effects, the novel dietary supplements are the new alternative approach to treat PCOS. Novel dietary supplements enriched with phytoestrogen help in alleviating the symptoms of PCOS such as improvement in ovulation, reduced blood glucose level, reduced stress level, and decreased weight. The present study was aimed to develop novel dietary supplements for women with PCOS. Aim and objective: To develop novel dietary supplements for women with PCOS by using underutilized ingredients. Materials and methods: Three different types of novel dietary supplements (supplement 1, supplement 2, and supplement 3) were developed under proper hygienic conditions. The organoleptic properties of the developed supplements were evaluated by the group of panel members. Followed by organoleptic evaluation, nutrient compositions were analyzed for the finalized supplement (supplement 3). Results: The nutrient composition of the finalized supplement was analyzed by using the standard procedure of AOAC (2016) and it is reported that the supplement is enriched with omega-3-fatty acid, polyphenols, flavonoids, selenium, iron, vitamin-A, and fiber. One-way ANOVA was used to analyze the significance between the formulated supplements and reported that the formulated supplements were statistically significant (p < 0.05). Conclusion: The study signifies that novel dietary supplements rich in phytoestrogens like polyphenols and flavonoids can be used for the treatment of PCOS. Clinical significance: Intake of developed supplement could result in regulation of menstruation and improvement in ovulation.

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Kalidoss, G., Velraja, S., & Narayanan, P. (2021). Development and formulation of phytoestrogen-rich supplement for women with polycystic ovary syndrome. International Journal of Infertility and Fetal Medicine, 12(2), 31–36. https://doi.org/10.5005/JP-JOURNALS-10016-1221

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