Optical label-free detection prevents the cost and complexity of fluorescence and radio labeling while providing accurate quantitative and kinetic results. We have developed a new optical label-free sensor called the liquid core optical ring resonator (LCORR). The LCORR integrates optical ring resonator sensors into the microfluidic delivery system by using glass capillaries with a thin wall. The LCORR is capable of performing refractive index detection on liquid samples, as well as bio/chemical analyte detection down to detection limits on the scale of pg/mm2 on a sensing surface.
CITATION STYLE
White, I. M., Zhu, H., Suter, J. D., Fan, X., & Zourob, M. (2009). Label-free detection with the liquid core optical ring resonator sensing platform. Methods in Molecular Biology (Clifton, N.J.), 503, 139–165. https://doi.org/10.1007/978-1-60327-567-5_7
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