Study the histopathogic effects of arsenic trioxide on some parenchymatous organs of male rats and under alphalipoic acid

Abstract

This study was designed to evaluate the histopathogical effects of arsenic trioxide (ATO) on the some organs of rats, for this reason group of rats (15) were I/P inoculated with 1.5 mg /Kg .B.wt. daily for 30 days other group( 15 rat) treated with 100 mg/kg.B.wt of alphalipoic acid and ATO ( 1.5 mg/ kg.B.wt) for 30 .The results was revealed that the extensive pathological lesions in the liver, kidney, spleen and testes in all rats exposed to arscenci trioxide due to the pathotoxic effect of ATO and decreased lesions were in the group treated with the alpha lipoic acid .100 mg / kg .B.wt) for 30 days as ameliorative or protective effect against pathotoxicity of ATO .