Negative regulation of human insulin gene expression by the 5′-flanking region in non-pancreatic cells

18Citations
Citations of this article
6Readers
Mendeley users who have this article in their library.

Abstract

We have examined the effect of the 5′-flanking region of the human insulin gene on its expression in non-pancreatic cells. The presence of the region containing the insulin gene enhancer (-339 to -169 bp) markedly repressed the promoter activity of the insulin gene. This suppressive phenomenon was restored by the addition of forskolin or dibutyryl cAMP, suggesting that this region alone is not sufficient to repress completely insulin gene expression in the presence of extracellular stimuli which increase the intracellular cAMP level. The hypervariable region (HVR) located at -365 bp also repressed the promoter activity. These results show negative regulation of human insulin gene expression in non-pancreatic cells by these regions. © 1989.

Cite

CITATION STYLE

APA

Takeda, J., Ishii, S., Seino, Y., Imamoto, F., & Imura, H. (1989). Negative regulation of human insulin gene expression by the 5′-flanking region in non-pancreatic cells. FEBS Letters, 247(1), 41–45. https://doi.org/10.1016/0014-5793(89)81236-0

Register to see more suggestions

Mendeley helps you to discover research relevant for your work.

Already have an account?

Save time finding and organizing research with Mendeley

Sign up for free