Evaluation of phthalate in breast milk and urine of lactating women in Egypt

Abstract

Phthalates are widely used in softening plastics especially it is cheap. But due to its harmful effect on health in many countries non phthalate plasticizers they are used instead in many products. As Phthalates rapidly metabolized and excreted in urine and feces.in the form of Monoesters (mono butyl phthalate) which can be measured in urine and breast milk using High Performance Liquid Chromatography (HPLC), So aim of our study to detect and counting of Mono-n-Butyl phthalate (MnBp) in the breast milk and urine of 20, randomly selected, lactating females house wife's with mean age of mothers from 17-39 years from Helwan Primary Health Center - Cairo - Egypt after their consent.. with detailed history regarding Sample analysis was conducted in The Micro Analytical Center - Faculty of Science - Cairo University using HPLC machine. As high non-occupational human exposures due to wide uses of phthalates is reported, so in our study we assess phthalate level in breast milk and urine in correlation with uses of personal care products(Cosmetics),Vinyl use in walls and in home flooring, drinking and eating in plastics containers and in relation to smoking. Our study shows a high statistically significant relation between phthalate level in mothers' urine and in breast milk with PVC or Vinyl use in walls and in home flooring, while its level in mothers' urine was highly significant in cases of drinking in plastic bottles and in eating in plastic containers. shows a high statistically significant relation between phthalate level in mothers' urine and in breast milk with PVC or Vinyl use in walls and in home flooring, while its level in mothers' urine was highly significant in cases of drinking in plastic bottles and in eating in plastic containers.