Abstract
The spread of aac(6′)-Ib-cr plasmid-mediated quinolone resistance determinants was evaluated in 197 enterobacterial isolates recovered in an Italian teaching hospital. The aac(6′)-Ib-cr gene was found exclusively in Escherichia coli strains. The gene was located on a plasmid which presented additional ESBL genes. Most of the clinical strains were clonally related and displayed three point mutations at the topoisomerase level which conferred high resistance to fluoroquinolones. © 2011 Frasson et al; licensee BioMed Central Ltd.
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Frasson, I., Cavallaro, A., Bergo, C., Richter, S. N., & Palù, G. (2011). Prevalence of aac(6′)-Ib-cr plasmid-mediated and chromosome-encoded fluoroquinolone resistance in Enterobacteriaceae in Italy. Gut Pathogens, 3(1). https://doi.org/10.1186/1757-4749-3-12
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