MicroRNA-137 inhibits BMP7 to enhance the epithelialmesenchymal transition of breast cancer cells

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Abstract

Bone morphogenetic protein-7 (BMP7) is known to antagonize transforming growth factor ß 1 (TGFß1)-mediated fibrosis through suppressing epithelialmesenchymal transition (EMT). We recently reported that BMP7 also antagonizes the effects of TGFß1 in breast cancer (BC) tumorigenesis-related EMT. Nevertheless, the control of BMP7 expression in BC remains ill-defined. Here, we detected significantly lower levels of BMP7 and significantly higher levels of microRNA-137 (miR-137) in the BC specimens, relative to paired adjacent non-tumor breast tissue. BMP7 and miR-137 levels were correlated inversely. Additionally, the high miR-137 levels in BC specimens were correlated with reduced patient survival. In vitro, overexpression of miR-137 significantly increased cell EMT and invasion, while depletion of miR-137 significantly decreased cell EMT and invasion in BC cells. The increases in BC cell invasiveness by miR-137 appeared to result from its suppression of BMP7, through direct binding of miR-137 to the 3'-UTR of BMP7 mRNA, thereby blocking its protein translation in BC cells. This study sheds light on miR-137 as a crucial factor that enhances BC cell EMT and invasiveness, and points to miR-137 as a promising innovative therapeutic target for BC treatment.

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Ying, X., Sun, Y., & He, P. (2017). MicroRNA-137 inhibits BMP7 to enhance the epithelialmesenchymal transition of breast cancer cells. Oncotarget, 8(11), 18348–18358. https://doi.org/10.18632/oncotarget.15442

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