Gut Microbiota Profiles in Nonalcoholic Fatty Liver Disease and Its Possible Impact on Disease Progression Evaluated with Transient Elastography: Lesson Learnt from 60 Cases

28Citations
Citations of this article
53Readers
Mendeley users who have this article in their library.

Abstract

Background: Dysbiosis of the gut microbiota has been considered to have a role in nonalcoholic fatty liver disease (NAFLD) progression. However, there is still lack of studies regarding this phenomenon. Aim: To find the difference in the proportion of gut microbiota in NAFLD patients based on the stages of liver fibrosis. Patients and Methods: A cross-sectional study was conducted at Dr. Cipto Mangunkusumo Hospital, which is the largest tertiary referral center. Human fecal samples from NAFLD patients who came to the outpatient clinic were collected consecutively. The stool sample examination was performed using an isolation DNA kit (Tiangen) and quantitative real-time polymerase chain reaction (Fast 7500). Clinical and laboratory data were also collected. The stage of fibrosis was diagnosed based on transient elastography (FibroScan® 502 Touch; Echosens, France). Results: Of 60 NAFLD human fecal samples, 35 patients had nonsignificant fibrosis and 25 patients had significant fibrosis (46.7% male and 53.3% female; median age 56 years). Most patients had diabetes (85%), dyslipidemia (58.3%), obesity (58.3%), and central obesity (90%). The proportion of Bacteroides was higher when compared to Lactobacillus and Bifidobacteria. Of these 3 microbiota, the proportion of Bacteroides was significantly higher in the significant fibrosis group when compared to the nonsignificant fibrosis group. Conclusion: There is a change in the composition of gut microbiota in NAFLD patients. The proportion of Bacteroides is significantly higher in significant liver fibrosis, which may play a role in NAFLD progression.

References Powered by Scopus

The role of short-chain fatty acids in the interplay between diet, gut microbiota, and host energy metabolism

3617Citations
N/AReaders
Get full text

The diagnosis and management of non-alcoholic fatty liver disease: Practice Guideline by the American Association for the Study of Liver Diseases, American College of Gastroenterology, and the American Gastroenterological Association

2937Citations
N/AReaders
Get full text

The multiple-hit pathogenesis of non-alcoholic fatty liver disease (NAFLD)

2273Citations
N/AReaders
Get full text

Cited by Powered by Scopus

The molecular and mechanistic insights based on gut–liver axis: Nutritional target for non-alcoholic fatty liver disease (NAFLD) improvement

88Citations
N/AReaders
Get full text

Understanding the effects of gut microbiota dysbiosis on nonalcoholic fatty liver disease and the possible probiotics role: Recent updates

80Citations
N/AReaders
Get full text

Role of the Gut Microbiota in Regulating Non-alcoholic Fatty Liver Disease in Children and Adolescents

58Citations
N/AReaders
Get full text

Register to see more suggestions

Mendeley helps you to discover research relevant for your work.

Already have an account?

Cite

CITATION STYLE

APA

Bastian, W. P., Hasan, I., Lesmana, R. A. C., Rinaldi, I., & Gani, R. A. (2019). Gut Microbiota Profiles in Nonalcoholic Fatty Liver Disease and Its Possible Impact on Disease Progression Evaluated with Transient Elastography: Lesson Learnt from 60 Cases. Case Reports in Gastroenterology, 13(1), 125–133. https://doi.org/10.1159/000498946

Readers' Seniority

Tooltip

PhD / Post grad / Masters / Doc 18

75%

Researcher 4

17%

Professor / Associate Prof. 2

8%

Readers' Discipline

Tooltip

Medicine and Dentistry 15

60%

Immunology and Microbiology 4

16%

Nursing and Health Professions 3

12%

Biochemistry, Genetics and Molecular Bi... 3

12%

Save time finding and organizing research with Mendeley

Sign up for free