Dismounting the MDR horse

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Abstract

P-gp (also termed MDR1, or multidrug resistance-1) is a member of the membrane ATP cassette family that mediates efflux of several drugs commonly used to treat AML. Its expression has been correlated with an adverse outcome, 1 which was thought to occur because it mediates resistance to chemotherapy.

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Libby, E., & Hromas, R. (2010, November 18). Dismounting the MDR horse. Blood. American Society of Hematology. https://doi.org/10.1182/blood-2010-09-304311

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