Non-viral causes of hepatocellular carcinoma

Abstract

Introduction: Hepatocellular carcinoma (HCC) is a major cause of cancer worldwide. The vast majority of cases occur in individuals with a chronic HBV or HCV infection. In addition, a number of metabolic diseases of the liver are associated with the development of HCC. Pathophysiologic Mechanisms: The mechanisms responsible for the progression of the metabolic liver disease and HCC differ from those associated with viral liver disease. Conclusions: The purpose of this report is to describe the mechanisms responsible for the disease progression and HCC in case of metabolic liver disease. A secondary goal is to identify the frequency of HCC development in the disorders described. © 2010 The Author(s).