Models of packed-bed bioreactors

Abstract

This chapter provides two case studies to show how modeling work can provide insights into how to design and operate traditional packed-beds and Zymotis-type packed-beds. Various other mathematical modeling case studies have been undertaken with packed-bed bioreactors: • Saucedo-Castaneda et al. (1990). A model of a thin packed-bed in which axial convection is not taken into account, rather only horizontal conduction through the walls. • Gutierrez-Rojas et al. (1995). A mathematical model for solid-state fermentation of mycelial fungi on inert support. • Hasan et al. (1998). Heat transfer simulation of solid-state fermentation in a packed-bed bioreactor. • Oostra et al. (2000). A model of a packed-bed bioreactor was used as part of the process of bioreactor selection. • Weber et al. (1999). A simplified material and energy balance approach for process development and scale-up of Coniothyrium minitans conidia production by solid-state cultivation in a packed-bed reactor. • Weber et al. (2002). Validation of a model for process development and scaleup of packed-bed solid-state bioreactor. The aim of this chapter is not to review these models. Readers with a deeper interest in modeling of packed-beds are recommended to find the original papers. © Springer-Verlag Berlin Heidelberg 2006.