Influence of cardiorespiratory fitness on PPARG mRNA expression using monozygotic twin case control

2Citations
Citations of this article
17Readers
Mendeley users who have this article in their library.

Abstract

The influence of cardiorespiratory fitness (VOax) on anthropometric variables and PPARG mRNA expression was investigated. Monozygotic twin pairs aged 11-18 years were grouped into discordant (D) and concordant (C) high and low VOax groups. VOax was determined by progressive maximal exercise test on treadmill with gas exchange analysis. Body mass (BM), BMI, waist circumference (WC), triceps (TR), and subscapular (SB) skinfold thicknesses were measured. Twins from the discordant group had differences in VOax values (D-high = 45.9±10.0 versus D-low = 32.4±10.6 mL·kg<sup>-1</sup>·min<sup>-1</sup>, P=0.025), while no differences were found in the concordant group (C-high = 42.4±9.2 versus C-low = 38.8±9.8 mL·kg<sup>-1</sup>·min<sup>-1</sup>, P=0.952). In discordant group, VOax was negatively correlated with TR + SB (r=-0.540, P=0.021) and positively correlated with PPARG expression in leukocytes (r=0.952, P=0.001). Moreover, PPARG expression was directly correlated with BM (r=0.714, P=0.047) and height (r=0.762, P=0.028). In concordant twins, VOax was inversely correlated with BM (r=-0.290, P=0.027), BMI (r=-0.472, P=0.001), WC (r=-0.426, P=0.001), and TR + SB (r=-0.739, P=0.001). Twins D-high had 1.78-fold greater PPARG expression when compared with twins D-low (P=0.048). In conclusion, the cardiorespiratory fitness may modulate PPARG expression in childhood and adolescence, independently of the genetic background.

Cite

CITATION STYLE

APA

Queiroga, M. R., Barbieri, R. A., Ferreira, S. A., Luchessi, A. D., Hirata, R. D. C., Hirata, M. H., & Kokubun, E. (2015). Influence of cardiorespiratory fitness on PPARG mRNA expression using monozygotic twin case control. Journal of Diabetes Research, 2015. https://doi.org/10.1155/2015/538732

Register to see more suggestions

Mendeley helps you to discover research relevant for your work.

Already have an account?

Save time finding and organizing research with Mendeley

Sign up for free