Treatment with 17 α-methyltestosterone and with some synthetic androgens prevents attacks of hereditary angioedema (HAE). However, the potential hepatotoxicity of 17 α-alkylated androgens raises the problem of long-term prophylactic use of these agents. Therefore we compared the efficacy in preventing HAE attacks of 17 α-alkylated steroids (danazol and stanozolol) with non-17 α-alkylated derivatives (quinbolone, nandrolone decanoate and mesterolone). As the latter group proved ineffective, it seems that a drug's efficacy in preventing HAE attacks is connected to its 17 α-alkylation. Moreover, our long-term observations with the minimum effective dose of danazol seem to indicate the absence of important collateral effects. © 1980.
Agostoni, A., Cicardi, M., Martignoni, G. C., Bergamaschini, L., & Marasini, B. (1980). Danazol and stanozolol in long-term prophylactic treatment of hereditary angioedema. The Journal of Allergy and Clinical Immunology, 65(1), 75–79. https://doi.org/10.1016/0091-6749(80)90181-5