Third Dentition Is the Main Cause of Premolar Supernumerary Tooth Formation

14Citations
Citations of this article
39Readers
Mendeley users who have this article in their library.

Abstract

While the prevalence of supernumerary teeth (ST) is high in permanent dentition, the etiology of ST in humans remains unclear. However, multiple murine models of ST have elaborated on dated mechanisms traditionally ascribed to ST etiology: one involves the rescue of rudimental teeth, and the second considers the contribution of odontogenic epithelial stem cells. It remains unclear whether these mechanisms of ST formation in mice are applicable to humans. The third dentition is usually regressed apoptotic—that is, the teeth do not completely form in humans. Recently, it was suggested that ST result from the rescue of regression of the third dentition in humans. The present investigation evaluates the proportion of collected general ST cases that evinced a third dentition based on the clinical definition of ST derived from the third dentition. We also investigated the contribution of SOX2-positive odontogenic epithelial stem cells to ST formation in humans. We collected 215 general ST cases from 15,008 patients. We confirmed that the general characteristics of the collected ST cases were similar to the results from previous reports. Of the 215 cases, we narrowed our analysis to the 78 patients who had received a computed tomography scan. The frequency of ST considered to have been derived from the third dentition was 26 out of 78 cases. Evidence of a third dentition was especially apparent in the premolar region, was more common in men, and was more likely among patients with ≥3 ST. SOX2-positive odontogenic epithelial stem cells within the surrounding epithelial cells of developing ST were observed in non–third dentition cases and not in third dentition cases. In conclusion, the third dentition is the main cause of ST in humans. The odontogenic epithelial stem cells may contribute to ST formation in cases not caused by a third dentition.

References Powered by Scopus

A solution to the problem of separation in logistic regression

1509Citations
N/AReaders
Get full text

A meta-analysis of the prevalence of dental agenesis of permanent teeth

719Citations
N/AReaders
Get full text

Localization of putative stem cells in dental epithelium and their association with Notch and FGF signaling

447Citations
N/AReaders
Get full text

Cited by Powered by Scopus

Anti-USAG-1 therapy for tooth regeneration through enhanced BMP signaling

23Citations
N/AReaders
Get full text

Development of tooth regenerative medicine strategies by controlling the number of teeth using targeted molecular therapy

15Citations
N/AReaders
Get full text

Stem cells in regenerative dentistry: Current understanding and future directions

5Citations
N/AReaders
Get full text

Register to see more suggestions

Mendeley helps you to discover research relevant for your work.

Already have an account?

Cite

CITATION STYLE

APA

Kiso, H., Takahashi, K., Mishima, S., Murashima-Suginami, A., Kakeno, A., Yamazaki, T., … Bessho, K. (2019). Third Dentition Is the Main Cause of Premolar Supernumerary Tooth Formation. Journal of Dental Research, 98(9), 968–974. https://doi.org/10.1177/0022034519858282

Readers' Seniority

Tooltip

PhD / Post grad / Masters / Doc 10

48%

Professor / Associate Prof. 6

29%

Researcher 3

14%

Lecturer / Post doc 2

10%

Readers' Discipline

Tooltip

Medicine and Dentistry 15

65%

Engineering 3

13%

Biochemistry, Genetics and Molecular Bi... 3

13%

Computer Science 2

9%

Save time finding and organizing research with Mendeley

Sign up for free