Formulation and Evaluation of Besifloxacin Loaded In Situ Gel For Ophthalmic Delivery

Abstract

The aim of study was to develop in situ gel of Besifloxacin by using blend polymer of sodium alginate, ethylcellulose and Xanthan gum to increase the pre-corneal residence time and better bioavailability of drug. In situ ocular gels of Besifloxacin (F1 to F6) were prepared by using polymers xanthan gum, Ethyl cellulose and sodium alginate in different ratio. The formulations F1 to F6 were evaluated for Clarity, visual appearance, pH, gelling capacity, drug content, assessment of drug release and ocular irritancy. The F1 to F6 were transparent and clear, and possessed a satisfactory gelling capacity. The drug content capacity for F1 to F6 ranged between 96.24% to 98.63%. The in vitro releases of drug from in situ ocular gel demonstrated that F3 (98.67%) has maximum drug release for 8 hrs compared to other formulations, and showed sustained release. The ocular irritancy study of F3 formulation showed non-irritant and safe to use. The studies suggested that prepared in situ ophthalmic gel of Besifloxacin will be an alternative for conventional eye drops and valuable alternative to counter the precorneal loss.