The effects of bisphenol A on sex hormone levels of F0 female rats and F1 male rats during weaning period

Abstract

The effects of bisphenol A (BPA) were examined on sex hormones of F1 generation male rats during weaning period. Female rats were exposed to BPA from day 0 after pregnancy to the weaning period at doses of 50, 100, or 200 mg kg -1. The sex hormone levels of F1 generation male rats were determined. This study shows that F0 generation female rats fed with 200 mg kg -1 BPA had a significantly higher serum prolactin (PRL) levels at the end of weaning. Significantly higher levels of serum estradiol (E 2) were also found in female rats fed 100 or 200 mg kg -1 BPA. Serum levels of E 2 in F1 male generation rats were higher in treatment groups compared to control groups while serum testosterone (T) levels were lower. Follicle stimulating hormone (FSH) in F1 generation rats fed 200 mg kg -1 was markedly decreased. The relative testicular weights were significantly less in 100 and 200 mg kg -1 BPA groups. BPA was found to alter the sex hormone levels in F1 male rats during weaning period and thus disrupted endocrine functions. © 2010 Taylor & Francis.