Purpose of Review: Obesity is a major risk factor for the development of hypertension (HTN), a leading cause of cardiovascular morbidity and mortality. Growing body of research suggests that adipose tissue function is directly associated with the pathogenesis of obesity-related HTN. In this review, we will discuss recent research on the role of adipose tissue in blood pressure (BP) regulation and activation of brown adipose tissue (BAT) as a potentially new therapeutic means for obesity-related HTN. Recent Findings: Adipose tissue provides mechanical protection of the blood vessels and plays a role in regulation of vascular tone. Exercise and fasting activate BAT and induce browning of white adipose tissue (WAT). BAT-secreted FGF21 lowers BP and protects against HTN. Browning of perivascular WAT improves HTN. Summary: New insights on WAT browning and BAT activation can open new avenues of potential therapeutic interventions to treat obesity-related HTN.
CITATION STYLE
Das, E., Moon, J. H., Lee, J. H., Thakkar, N., Pausova, Z., & Sung, H. K. (2018, November 1). Adipose Tissue and Modulation of Hypertension. Current Hypertension Reports. Current Medicine Group LLC 1. https://doi.org/10.1007/s11906-018-0894-7
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