Asymmetric synthesis of tertiary thiols and thioethers

Abstract

Enantiomerically pure tertiary thiols provide a major synthetic challenge, and despite the importance of chiral sulfur-containing compounds in biological and medicinal chemistry, surprisingly few effective methods are suitable for the asymmetric synthesis of tertiary thiols. This review details the most practical of the methods available. © 2011 Clayden and MacLellan; licensee Beilstein-Institut.