Temporary storage of fresh frozen plasma above -30°C has no negative impact on the quality of clotting factors and inhibitors

Abstract

Fresh frozen plasma (FFP) should be stored at temperatures > -30°C according to national and international guidelines to maintain the stability of clotting factors and inhibitors. In the present report, FFP was accidentally stored at < -30°C due to icing of the freezer. To ensure the quality of the FFPs a battery of tests of clotting factors and inhibitors was performed. Our data demonstrate that temporary storage of FFP at temperature < -30°C does not negatively affect the quality of FFPs. The European requirement of 70% activity of factor VIII was met by all units. © 2010 The Authors. Journal Compilation © 2010 Medical Education Global Solutions.