Quantitative handheld swept-source optical coherence tomography angiography in awake preterm and full-term infants

14Citations
Citations of this article
26Readers
Mendeley users who have this article in their library.
Get full text

Abstract

Purpose: To compare retinal vascular parameters acquired by handheld swept-source optical coherence tomography angiography (SS-OCTA) between nonsedated preterm and full-term infants. Methods: Preterm and full-term infants at the University of Washington Medical Center were enrolled. Retinal angiograms (nominal size ~7 × 7 mm2 ) were obtained at each routine retinopathy of prematurity (ROP) screening session for preterms and once during the first 72 hours of life for full-terms. Macular vessel area density and nonperfusion area were evaluated on the binarized vasculature map in both small (1.5 × 1.5 mm) and large (3 × 3 mm) quadrants. Average vessel diameter and tortuosity values were obtained from each large vessel branch (length >200 μm). All vascular analyses used previously published algorithms. Results: Handheld SS-OCTA captured 31 of 55 (56%) high-quality volumes on 8 awake preterm infants (gestational age 28 ± 4 weeks, birth weight 891 ± 314 g, postmenstrual age at first imaging session 37 ± 2 weeks) and 48 of 54 (89%) volumes on 12 awake full-term infants (gestational age 39 ± 1 weeks, birth weight 3405 ± 329 g). Signal-tonoise ratio was 5.08 ± 1.52 dB in preterm and 4.90 ± 1.12 dB in full-term infants. Preterm infants had higher mean large vessel tortuosity compared to full-term infants (P = 0.004). The large nasal quadrant vessel area density of infants with stage 3 and/or pre-plus or worse ROP was higher than other preterm infants (P = 0.007). Conclusions: Although inadequate image quality limited usable imaging sessions, handheld SS-OCTA achieved adequate signal-to-noise ratio in nonsedated infants for quantitative retinal vascular parameter analysis. Translational Relevance: Large-and small-vessel parameters were associated with prematurity and ROP severity, respectively.

Cite

CITATION STYLE

APA

Zhou, K., Song, S., Legocki, A., Cheng, Y., Ding, L., Rezaei, K. A., … Cabrera, M. T. (2020). Quantitative handheld swept-source optical coherence tomography angiography in awake preterm and full-term infants. Translational Vision Science and Technology, 9(13), 1–13. https://doi.org/10.1167/tvst.9.13.19

Register to see more suggestions

Mendeley helps you to discover research relevant for your work.

Already have an account?

Save time finding and organizing research with Mendeley

Sign up for free