Circulating adipokines are associated with Kawasaki disease

Abstract

Background: The pathogenesis of Kawasaki disease are still not well understood. It was designed to investigate the relationship between adipokines including chemerin, omentin-1, adiponectin and acute Kawasaki disease. Methods: Enzyme-linked immunosorbent (ELISA) was used to detect serum levels of chemerin, omentin-1, adiponectin, and inflammatory cytokines IL-1β and TNF-α in 80 cases of patients diagnosed with Kawasaki disease (KD). In addition, 20 cases of children with fever and 20 cases of healthy children were selected as febrile and normal controls. Results: (1) Serum levels of chemerin in KD group (87.736±56.310) are higher than that of both the healthy (41.746±10.824) and the febrile controls (59.683±18.282) (P<0.01). (2) Circulating omentin-1 levels in Kawasaki disease group (389.773±238.611) are significantly lower than that of febrile control (542.075±177.995) (P<0.01), also serum adiponectin levels in Kawasaki disease group (16.400±12.243) reduced obviously compared with the febrile control group (35.074±12.486). (3)Serum cytokine levels of IL-1β in Kawasaki disease group (13.656±31.151) are higher than those of normal controls (2.415±6.313) (P<0.05). (4) Correlation analysis indicates that serum levels of chemerin are positively correlated with omentin-1 (r=0.224, 95% CI 0.06-0.529, P<0.05). Further, serum omentin-1 levels and total cholesterol (TC) are positively correlated (r=0.358, 95% CI 0.169-0.518, P<0.01). Conclusions: Circulating chemerin increased significantly in the acute stage of Kawasaki disease, while omentin-1 and adiponectin levels are decreased. These adipokines are closely associated with the early inflammation and lipid metabolism disorders of acute Kawasaki disease.