This study evaluated the effects of Pycnogenol as an adjunct to angiotensin-converting enzyme (ACE)-inhibitor ramipril treatment of hypertensive patients presenting with early signs of renal function problems. One group of 26 patients was medicated with 10 mg ramipril per day only; a second group of 29 patients took Pycnogenol in addition to the ACE inhibitor over a period of 6 months. At trial end, a lowered systolic and diastolic blood pressure was found in both groups, with a significant further reduction of diastolic pressure in the group given Pycnogenol in addition to ramipril. The major aim of this study was the investigation of kidney-protective effects of Pycnogenol. Urinary albumin decreased from 87 ± 23 to 64 ± 16 mg/d with ramipril only. Additional Pycnogenol lowered albumin significantly better from 91 ± 25 to 39 ± 13 mg/day (P
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Cesarone, M. R., Belcaro, G., Stuard, S., Scḧnlau, F., Di Renzo, A., Grossi, M. G., … Pellegrini, L. (2010). Kidney flow and function in hypertension: Protective effects of pycnogenol in hypertensive participants-a controlled study. Journal of Cardiovascular Pharmacology and Therapeutics, 15(1), 41–46. https://doi.org/10.1177/1074248409356063
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