Specific Sensitization Age Dynamic in Patients with Atopic Dermatitis

Abstract

Background: Specific sensitization characterizes increased serum level of IgE to different groups of allergens (food, dust, domestic and contact). Characteristic of specific sensitization changes with age of patient. Spectrum of specific sensitization determined environmental factors, conditions of habitation.Objective: objective was to research characteristic of specific sensitization in patients with atopic dermatitis.Methods: There were 108 patients with atopic dermatitis, 1st group – 31 patient (17 boys and 14 girls) 0-3y.o., 2nd group – 30 (13 boys and 17 girls) 4-13 y.o., 3rd group – 47 (16 men and 31 women) 16-63 y.o. In control group, there were 25 patients (4 men, 21 women) 16-64 y.o. with another dermatological diseases such as psoriasis, acne, rosacea and etc., without atopic dermatitis. In patients of all 4 groups evaluated personal, family allergic anamnesis, drug and food allergy, sensitization by measuring common and specific levels of immunoglobulin E.Results: 10%, 32%, 27% patients of 1st, 2nd, 3rd groups had food allergy. The main allergens were citruses (37% cases), chocolate (27%) and milk (17%).Conclusion: 44-52% patients with atopic dermatitis and 4% patients without atopy had non-specific sensitization, that characterized five-fold increased serum level of IgE and more.50-60% patients with atopic dermatitis had specific sensitization. 60% infants at the age under 3 y.o. with atopic dermatitis had sensitization for epithelium of homepets, 50% - for milk, 30% - white-egg. Among adults with atopic dermatitis sensitization was the same, as in control group. 35% patients with dermatoses without atopy had specific sensitization.