Dysregulation of HIF2α and autophagy in renal cell carcinoma

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Abstract

Our recent study shows that autophagy collaborates with proteasomes to degrade endothelial PAS domain-containing protein 1 (EPAS1, also known as HIF2α) in a manner dependent on Von Hippel-Lindau (VHL) and sequestosome 1 (SQSTM1/p62). The genetic dysregulation of autophagy is a common feature of different subtypes of renal cell carcinoma (RCC).

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Liu, X. D., Zhu, H., DePavia, A., & Jonasch, E. (2015). Dysregulation of HIF2α and autophagy in renal cell carcinoma. Molecular and Cellular Oncology, 2(2). https://doi.org/10.4161/23723548.2014.965643

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