Differences in Physico-Chemical Properties and Immunological Response in Nanosimilar Complex Drugs: The Case of Liposomal Doxorubicin

2Citations
Citations of this article
10Readers
Mendeley users who have this article in their library.

Abstract

This study aims to highlight the impact of physicochemical properties on the behaviour of nanopharmaceuticals and how much carrier structure and physiochemical characteristics weigh on the effects of a formulation. For this purpose, two commercially available nanosimilar formulations of Doxil and their respective carriers were compared as a case study. Although the two formulations were “similar”, we detected different toxicological effects (profiles) in terms of in vitro toxicity and immunological responses at the level of cytokines release and complement activation (iC3b fragment), that could be correlated with the differences in the physicochemical properties of the formulations. Shedding light on nanosimilar key quality attributes of liposome-based materials and the need for an accurate characterization, including investigation of the immunological effects, is of fundamental importance considering their great potential as delivery system for drugs, genes, or vaccines and the growing market demand.

References Powered by Scopus

Doxil® - The first FDA-approved nano-drug: Lessons learned

3688Citations
N/AReaders
Get full text

Liposome: Classification, preparation, and applications

2779Citations
N/AReaders
Get full text

Advances and challenges of liposome assisted drug delivery

1939Citations
N/AReaders
Get full text

Cited by Powered by Scopus

Flotation Coefficient Distributions of Lipid Nanoparticles by Sedimentation Velocity Analytical Ultracentrifugation

5Citations
N/AReaders
Get full text

Pulmonary Delivery of Antibiotics to the Lungs: Current State and Future Prospects

0Citations
N/AReaders
Get full text

Register to see more suggestions

Mendeley helps you to discover research relevant for your work.

Already have an account?

Cite

CITATION STYLE

APA

Lipsa, D., Magrì, D., Della Camera, G., La Spina, R., Cella, C., Garmendia-Aguirre, I., … Gioria, S. (2023). Differences in Physico-Chemical Properties and Immunological Response in Nanosimilar Complex Drugs: The Case of Liposomal Doxorubicin. International Journal of Molecular Sciences, 24(17). https://doi.org/10.3390/ijms241713612

Readers over time

‘23‘24‘2501234

Readers' Seniority

Tooltip

Researcher 3

75%

PhD / Post grad / Masters / Doc 1

25%

Readers' Discipline

Tooltip

Biochemistry, Genetics and Molecular Bi... 2

50%

Chemical Engineering 1

25%

Physics and Astronomy 1

25%

Article Metrics

Tooltip
Mentions
Blog Mentions: 1
News Mentions: 1

Save time finding and organizing research with Mendeley

Sign up for free
0