The relationship between vitamin D level and organ-specifi c autoimmune disorders in newly diagnosed type I diabetes mellitus

Abstract

INTRODUCTION: The purpose of our study is to determine vitamin D levels in patients with newly diagnosed type 1 DM, and assess the association of type 1 DM with organ-specifi c autoimmune disorders, as well as their association with vitamin D. MATERIAL AND METHODS: We included a total of 160 patients, of whom 50 were newly diagnosed with type 1 DM (group I), 50 were formerly diagnosed with type 1 DM (group II), and 60 were healthy controls (group III). RESULTS: The mean level of 25(OH)D was 14.6 ng/dL in group I, 12.1 ng/dL in group II, and 16.1 ng/dL in group III. In all diabetic patients, the 25(OH)D levels were lower than those of controls. The 25(OH)D median level was 11.4 ng/ml in all cases included into the study with ATD. In subjects without ATD, the latter level was 15.3 ng/ml. The difference was found to be statistically signifi cant. CONCLUSIONS: In this study, the vitamin D level was lower in (i) type 1 diabetic patients when compared with healthy subjects, (ii) all cases included to study with ATD when compared with patients without ATD, (iii) all APA-positive type 1 diabetic patients with ATD when compared with none (iv) APA-positive newly diagnosed type 1 diabetics when compared with those APA-negative.