Outcomes in postoperative pediatric cardiac surgical patients who received an antiepileptic drug

5Citations
Citations of this article
13Readers
Mendeley users who have this article in their library.
Get full text

Abstract

BACKGROUND: Advances in cardiac operations over the last few decades, including corrective operations in early life, have dramatically increased the survival of children with congenital heart disease. However, postoperative care has been associated with neurologic complications, with seizures being the most common manifestation. The primary objective of this study is to describe the outcomes in pediatric patients who received an antiepileptic drug (AED) post–cardiac surgery. METHOD: A retrospective cohort study was performed in all patients less than 18 years of age who received an AED in the cardiovascular intensive care unit at Texas Children’s Hospital from June 2002 until June 2012. Cardiac surgical patients initiated on phenobarbital, phenytoin, and levetiracetam were queried. Patients were excluded if the AED was not initiated on the admission for surgery. Patients who received 1 AED were compared to patients who received 2 AED, and differences in outcomes examined between the 3 AEDs used were evaluated. RESULTS: A total of 37 patients met the study criteria. Patients were initiated on an AED a median of 4 days following surgery and became seizure free a median of 1 day after initiation, with 65% remaining seizure free after the first dose. Half of all patients required 2 AEDs for seizure control, with a higher proportion of adolescents requiring 2 AEDs (p = 0.04). No differences were found when comparing the collected outcomes between phenobarbital, fosphenytoin, or levetiracetam. CONCLUSION: No adverse events were reported with the AEDs reviewed. Further work is necessary to evaluate long-term neurodevelopmental outcomes in this population and whether outcomes are a result of the AED or of other clinical sequelae.

References Powered by Scopus

Consensus-based method for risk adjustment for surgery for congenital heart disease

1162Citations
N/AReaders
Get full text

A Comparison of the Perioperative Neurologic Effects of Hypothermic Circulatory Arrest versus Low-Flow Cardiopulmonary Bypass in Infant Heart Surgery

640Citations
N/AReaders
Get full text

Neuro developmental outcomes after cardiac surgery in infancy

405Citations
N/AReaders
Get full text

Cited by Powered by Scopus

Frequency and outcome of acute neurologic complications after congenital heart disease surgery

9Citations
N/AReaders
Get full text

Incidence of neurological complications following pediatric heart surgery and its association with neutrophil-to-lymphocyte ratio

7Citations
N/AReaders
Get full text

Incidence of Acute Neurological Events in Neonates and Infants Undergoing Cardiac Surgery Using a High-Hematocrit/ High-Flow Bypass Strategy

4Citations
N/AReaders
Get full text

Register to see more suggestions

Mendeley helps you to discover research relevant for your work.

Already have an account?

Cite

CITATION STYLE

APA

Messinger, M. M., Dinh, K. L., McDade, E. J., Moffett, B. S., Wilfong, A. A., & Cabrera, A. G. (2016). Outcomes in postoperative pediatric cardiac surgical patients who received an antiepileptic drug. Journal of Pediatric Pharmacology and Therapeutics, 21(4), 327–331. https://doi.org/10.5863/1551-6776-21.4.327

Readers' Seniority

Tooltip

PhD / Post grad / Masters / Doc 5

71%

Professor / Associate Prof. 1

14%

Researcher 1

14%

Readers' Discipline

Tooltip

Medicine and Dentistry 5

56%

Nursing and Health Professions 2

22%

Pharmacology, Toxicology and Pharmaceut... 1

11%

Sports and Recreations 1

11%

Article Metrics

Tooltip
Social Media
Shares, Likes & Comments: 14

Save time finding and organizing research with Mendeley

Sign up for free