A bacterial mutation affecting λ DNA replication, called groPC756, has been mapped between the thr and leu bacterial loci. Most of the parental λ DNA does not undergo even one round of replication in this host. Lambda mutants, called π, which map in the λ P gene are able to overcome the inhibitory effect of the groPC756 mutation. It is shown that the mutation at the groPC locus also interferes with bacterial growth at 42°C. A λ-transducing phage, carrying the groPC+ allele, was isolated as a plaqueformer on groPC756 bacteria. Upon lysogenization, it restores both the gro+ and temperature resistant phenotypes. © 1977 Springer-Verlag.
CITATION STYLE
Georgopoulos, C. P. (1977). A new bacterial gene (groPC) which affects λ DNA replication. MGG Molecular & General Genetics, 151(1), 35–39. https://doi.org/10.1007/BF00446910
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