Periodontitis is associated with an increased risk for proximal colorectal neoplasms

24Citations
Citations of this article
42Readers
Mendeley users who have this article in their library.

This article is free to access.

Abstract

Interval colorectal cancers detected after colonoscopy are known to be highly associated with proximal colorectal neoplasms (CRNs). This cross-sectional study investigated whether periodontitis could be a risk factor for proximal CRNs in healthy individuals. A total of 2504 subjects who received a colonoscopy and dental exam were enrolled in this study. We divided the subjects into the periodontitis group (n = 216) and the control group (n = 2288). The periodontitis group was defined as subjects who had one or more teeth with a probing pocket depth (PPD) ≥4 mm. The prevalence of proximal CRNs was significantly higher in the periodontitis group (25.0%) than in the control group (12.3%) (P < 0.001). Independent risk factors for proximal CRNs in the multivariate analysis were periodontitis, smoking, age, waist circumference, and triglycerides, and those for proximal advanced CRNs were periodontitis, age, and family history of CRC. However, periodontitis was not a risk factor for overall CRNs and advanced CRNs. Periodontitis was associated with an increased risk of proximal CRNs (odds ratio [OR], 1.525; 95% confidence intervals [95% CI], 1.071–2.172) and proximal advanced CRNs (OR, 2.671; 95% CI, 1.088–6.560). Periodontitis might be associated with proximal CRNs and proximal advanced CRNs.

Cite

CITATION STYLE

APA

Kim, G. W., Kim, Y. S., Lee, S. H., Park, S. G., Kim, D. H., Cho, J. Y., … Yoo, J. H. (2019). Periodontitis is associated with an increased risk for proximal colorectal neoplasms. Scientific Reports, 9(1). https://doi.org/10.1038/s41598-019-44014-8

Register to see more suggestions

Mendeley helps you to discover research relevant for your work.

Already have an account?

Save time finding and organizing research with Mendeley

Sign up for free