Antifungal activity and theoretical study of synthesized pyrazole-imidazole hybrids

Abstract

The density functional theory (DFT) and thermodynamic analyses were applied to study the stability and chemical reactivity of the synthesized CMPIP {2-chloro-4-(4-(1-methyl-1Hpyrazole- 4-yl)-1H-imidazole-5-yl) pyridine} and MPIMPPA {4-(4-(1-methyl-1H-pyrazole-4-yl)- 1H-imidazole-5-yl)-N-(4-morpholino phenyl) pyridin-2-amine} . The results concluded that the CMPIP compound is more stable than MPIMPPA. The antifungal study was confirmed that the MPIMPPA has a higher inhibition zone against Aspergillus niger (A. niger), as compared to the standard drug used, while the CMPIP compound showed weaker activity than the positive control.