Synthesis and biological studies of inducible DNA cross-linking agents

Abstract

(Chemical Equation Presented) Checking the traps: When a phenyl selenide compound such as 1 was oxidized with sodium periodate or irradiated, an ortho-quinone methide intermediate formed and reacted with a DNA duplex by cross-linking. In the crystal structure of a derivative of 1 the biphenyl unit is twisted, and this might explain how 1 can interact effectively with the DNA backbone. © 2007 Wiley-VCH Verlag GmbH & Co. KGaA.