Formulation development and in vitro evaluation of mouth dissolving tablets of loratadine

Abstract

Selection of a suitable pharmacotherapy for a particular ailment is always followed by opting for most convenient dosage form. In continuous quest for engineering more and more convenient and efficient dosage systems, mouth dissolving tablets is one of most unique dosage form invented with advantages including rapid disintegration without use of vehicle and is suitable choice for patients suffering from dysphagia. The aim of this study was to formulate and evaluate the mouth dissolving tablets of loratadine-anti histamine. Three super disintegrants which are croscarmellose sodium, crospovidone and sodium starch glycolate in ratios 2%, 4% and 6% were used. The prepared batches of tablets were assessed. Formulation with 4% crospovidone was discovered to be most efficient with 17.6 s disintegration time in simulated saliva which was statistically significant than the rest of the formulations with p value < 0.001 whereas in vitro disintegration time was noted to be 12 s.