Meal induced oxidative stress levels in controlled and poorly controlled diabetes

Abstract

Objective: The postprandial (PP) metabolic derangements are accentuated in Type 2 diabetes and are important risk factors for cardiovascular disease since they induce oxidative stress and endothelial dysfunction. The aim of the study was to analyze meal induced oxidative stress levels in controlled and poorly controlled diabetes. Methods: Total 60 Type 2 diabetic patients on oral hypoglycemics of duration 5-15 years were divided into two groups based on hemoglobin A1c values (≤7.5% for controlled/Group 1 and ≥7.6% for poorly controlled/Group 2). They were assayed for serum/plasma glucose, thiobarbituric acid reacting substances (TBARS) and oxidized low-density lipoprotein (ox-LDL) parameters both in fasting and 2 hrs post meal in both groups. Statistical analysis was performed using independent t-test between the groups and paired t-test within each group. Results: The PP TBARS were found significantly higher in both groups, whereas no significant difference between the two groups. The ox-LDL levels were found similar at two points of time in both groups. Conclusion: An exaggerated PP oxidative stress levels are associated with diabetes and its complications including endothelial dysfunction.