Cefoperazone metal complexes: Synthesis and characterization

Abstract

Cefoperazone (Hcefopz) interacts with transition metal(II) ions to give [M(cefopz)Cl] complexes (M = Fe, Co, Ni, Cu and Cd) and [Fe(cefopz)Cl]Cl which were characterized by physicochemical and spectroscopic methods. The spectra indicated that the antibiotics act as monoanionic multidentate NO3 chelating agent towards metal ions, via the amides, and carboxylate and N-azomoiety. The complexes are non-toxic, insoluble in water and common organic solvents and probably have polymeric structures.