Effects of a rehabilitation program on microvascular function of CHD patients assessed by near-infrared spectroscopy

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Abstract

This study aimed to evaluate whether near-infrared spectroscopy (NIRS)-derived reperfusion slope would detect the effects of a 12-week rehabilitation program on lower limb microvascular responsiveness in patients with coronary heart disease (CHD). Ten CHD patients (7 males and 3 females; 57.3 ± 7.6 years) underwent 12 weeks of drug treatment and high-intensity interval training (HIIT), 2 times per week (40 min/session). Microvascular responsiveness was assessed by using NIRS assessment of muscle oxygen saturation (StO2) combined with a vascular occlusion test (VOT) (NIRS-VOT). NIRS-VOT measures were taken at pre- and postintervention, and microvascular responsiveness was evaluated by examining the slope 2 of re-oxygenation rate (slope 2 StO2) and the area under the curve (StO2AUC) of StO2 signal following cuff release subsequent to a 5-min occlusion period. The slope 2 StO2 was significantly steeper after 12 weeks of training (4.8 ± 1.6% sec−1) compared to the pretraining (3.1 ± 1.6% sec−1) (P < 0.05). The area under the curve for the change in the % StO2 signal during re-oxygenation increased significantly from 3494 ± 2372%∙sec at pretraining to 9006 ± 4311%∙sec at post-training (P < 0.05). NIRS-VOT technique detected the improvements of 12 weeks of rehabilitation program in the lower limb microvascular responsiveness of CHD patients.

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Soares, R. N., Murias, J. M., Saccone, F., Puga, L., Moreno, G., Resnik, M., & De Roia, G. F. (2019). Effects of a rehabilitation program on microvascular function of CHD patients assessed by near-infrared spectroscopy. Physiological Reports, 7(11). https://doi.org/10.14814/phy2.14145

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