Biodegradable FeMnSi sputter-coated macroporous polypropylene membranes for the sustained release of drugs

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Abstract

Pure Fe and FeMnSi thin films were sputtered on macroporous polypropylene (PP) membranes with the aim to obtain biocompatible, biodegradable and, eventually, magnetically-steerable platforms. Room-temperature ferromagnetic response was observed in both Fe- and FeMnSi-coated membranes. Good cell viability was observed in both cases by means of cytotoxicity studies, though the FeMnSi-coated membranes showed higher biodegradability than the Fe-coated ones. Various strategies to functionalize the porous platforms with transferrin-Alexa Fluor 488 (Tf-AF488) molecules were tested to determine an optimal balance between the functionalization yield and the cargo release. The distribution of Tf-AF488 within the FeMnSi-coated PP membranes, as well as its release and uptake by cells, was studied by confocal laser scanning microscopy. A homogeneous distribution of the drug within the membrane skeleton and its sustained release was achieved after three consecutive impregnations followed by the addition of a layer made of gelatin and maltodextrin, which prevented exceedingly fast release. The here-prepared organic-inorganic macroporous membranes could find applications as fixed or magnetically-steerable drug delivery platforms.

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Fornell, J., Soriano, J., Guerrero, M., Sirvent, J. de D., Ferran-Marqués, M., Ibáñez, E., … Pellicer, E. (2017). Biodegradable FeMnSi sputter-coated macroporous polypropylene membranes for the sustained release of drugs. Nanomaterials, 7(7). https://doi.org/10.3390/nano7070155

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