Significance of αIIbβ3 in subacute stent thrombosis after percutaneous coronary intervention

Abstract

Soluble P-selectin and whole blood aggregation (WBA) were measured after percutaneous coronary intervention in patients who then received antiplatelet therapy. One had subacute thrombosis on day 7. This patient's WBA exhibited time-dependent enhancement. In addition, the accentuation of WBA on day 3 was observed when anti-αIIbβ3 antibody was added. The remaining 22 patients were divided according to WBA results on day 3 with anti-αIIbβ3 antibody added (A group, WBA enhanced; B group, WBA did not enhance). WBA on day 3 was similar in the two groups. The ratio of WBA with and without anti- αIIbβ3 antibody was higher in group A than in group B. A significant time-dependent increase of soluble P-selectin was observed in the A group. These results suggest that enhancement of WBA with anti-αIIbβ3 antibody after percutaneous coronary intervention predicts subacute thrombosis. ©2005 Westminster Publications, Inc.