(Matrix Presented) Dihydroxylation under ruthenium catalysis provides an easy access to syn-diols, although overoxidation is a common side reaction. Furthermore, the high catalyst loadings offset the lower price of ruthenium compared to osmium. In this paper, we present an improved protocol for the RuO4-catalyzed syn-dihydroxylation using only 0.5 mol % catalyst under acidic conditions. A variety of olefins can be hydroxylated in good to excellent yields with only minor formation of side products.
CITATION STYLE
Plietker, B., & Niggemann, M. (2003). An improved protocol for the RuO4-catalyzed dihydroxylation of olefins. Organic Letters, 5(18), 3353–3356. https://doi.org/10.1021/ol035335a
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