Studies have shown that progesterone reduces brain injury, whereas testosterone increases lesion size after ischemic stroke. This study examined the effects of progesterone and testosterone on intracerebral hemorrhage (ICH)-induced brain injury. Male Sprague-Dawley rats received an injection of 100 μL autologous whole blood into the right basal ganglia. Progesterone (16 mg/kg), testosterone (15 mg/kg) or vehicle was given intraperitoneally 2 h after ICH. Behavioral tests were performed, and the rats were killed after 24 h for brain edema measurement. Perihematomal brain edema was reduced in progesterone-treated rats compared to vehicle-treated rats (p < 0.05). Progesterone also improved functional outcome following ICH (p < 0.05). Testosterone treatment did not affect perihematomal edema formation, but resulted in lower forelimb placing score (p < 0.05). In conclusion, progesterone can reduce brain edema and improve functional outcome, whereas testosterone may have a deleterious effect after ICH in male rats. © 2011 Springer-Verlag/Wien.
CITATION STYLE
Chen, Z., Xi, G., Mao, Y., Keep, R. F., & Hua, Y. (2011). Effects of progesterone and testosterone on ICH-induced brain injury in rats. In Acta Neurochirurgica, Supplementum (pp. 289–293). Springer-Verlag Wien. https://doi.org/10.1007/978-3-7091-0693-8_48
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