Matrix Metalloproteinases: Mediators of Tumour-Host Cell Interactions

Abstract

Matrix metalloproteinases (MMPs) are a family of metalloendopeptidases that induce remodelling of extracellular matrix (ECM) and differentially cleave many soluble mediators that regulate cell physiology. Due to their matrix-degrading capabilities and elevated expression levels in both neoplastic and host cells in human cancer, MMPs have acquired considerable attention as targets for anti-cancer therapy. This chapter summarizes two decades of research examining MMP biochemistry and biology utilizing in vitro cell-based and biochemical analyses, more recent examination of their functional significance in de novo mouse models of human cancer development and results from human clinical trials where MMP inhibitors were evaluated for efficacy as anti-cancer therapeutics.