The mechanism of closure of the mitral valve: A continuing controversy

Abstract

Mitral valve closure has intrigued investigators since William Harvey compared the structure to the valves of a mechanical force pump. Chauveau and Fivre extended this analogy in 1856 by postulating that mitral closure was produced by the systolic increase in ventricular pressure. This classic 'ventriculogenic' explanation of closure was challenged, and by the beginning of this century several other mechanisms had been proposed. Despite advances in investigative techniques, these same explanations are still widely advocated, and a unanimous decision on the mechanism of mitral valve closure is not available. In this brief review author highlights the state of uncertainty and suggest the need for further study.