Calculation of survival probabilities for cells exposed to high ion fluences

Abstract

Abstract: A methodology of calculations of survival curves with an account for ion tracks interference is developed using the multiscale approach to the physics of radiation damage with ions. The method is applied to cells, for which shouldered survival curves are obtained; however, it can be applied to plasmid DNA and other targets. The recipe is designed for both high and low values of linear energy transfer. Graphical abstract: [Figure not available: see fulltext.].