The SOCS-1-1478CA/del polymorphism is not associated with colorectal cancer or age at onset in turkish subjects

Abstract

Background: Suppressor of cytokine signaling (SOCS)-1 acts as a key regulator of many cytokine signaling pathways and its abnormal expression has been identified in several human malignancies, suggesting potential roles in carcinogenesis. The aim of this study was to investigate any association between the functional SOCS- 1-1478CA> del polymorphism in the pathogenesis of CC in Turkish subjects.