Purification of Physiologically Active Chitosan Oligosaccharides by Means of Nanofiltration Membrane

Abstract

We used nanofiltration membranes to study the purification of physiologically active chitosan oligosaccharides (pentamers and hexamers). Calculations based on the experimental data of batch filtration suggested that the con-tent of the target oligosaccharides in the product mixture could be improved from 30% to 77% by continuous diafiltra-tion under optimized conditions.