Total, Bioavailable, and Free 25(OH)D Relationship with Indices of Bone Health in Elderly: A Randomized Controlled Trial

18Citations
Citations of this article
35Readers
Mendeley users who have this article in their library.

Abstract

Context: Questions regarding the superiority of free and bioavailable 25-hydroxyvitamin D [25(OH)D] in predicting health outcomes remain unresolved. Objective: This study investigates the impact of vitamin D variables - total, bioavailable, or free 25(OH)D - on indices of bone and mineral metabolism, at baseline and in response to 2 vitamin D doses. Design: Our objectives are implemented as exploratory analyses on data collected in a 1-year, double-blind, randomized controlled trial completed in July 2014. Setting: Participants were recruited from 3 major hospitals in an ambulatory setting. Participants: Participants were >65 years of age, overweight, and had a baseline serum 25(OH)D between 10 and 30 ng/mL. A total of 221 participants completed the study. Intervention: Subjects were randomized to receive calcium and oral vitamin D3 (600 IU/day or 3750 IU/day) supplementation. Results: Participants who received the higher vitamin D dose had levels that were 1.3- to 1.4-fold higher than those taking the lower dose, for all variables (P value<0.001). Serum values of bioavailable and free 25(OH)D were associated with total 25(OH)D, with r values of 0.942 and 0.943, respectively (P value<0.001). Parathyroid hormone (PTH) was negatively associated with all vitamin D variables, with correlation coefficients ranging from -0.22 to -0.25, while calcium and bone turnover markers (carboxy-terminal collagen crosslinks and osteocalcin) did not. Only total 25(OH)D had a positive relationship with % change bone mineral density (BMD) at the femoral neck at 12 months, while only free and bioavailable 25(OH) had a positive relationship with % change total body BMD at 12 months. Conclusion: Calculated free and bioavailable 25(OH)D do not appear to be superior to total 25(OH)D in predicting indices of bone health in an elderly population.

References Powered by Scopus

Medical progress: Vitamin D deficiency

11785Citations
N/AReaders
Get full text

Evaluation, treatment, and prevention of vitamin D deficiency: An endocrine society clinical practice guideline

8307Citations
N/AReaders
Get full text

The 2011 report on dietary reference intakes for calcium and vitamin D from the Institute of Medicine: What clinicians need to know

3400Citations
N/AReaders
Get full text

Cited by Powered by Scopus

Consensus Statement on Vitamin D Status Assessment and Supplementation: Whys, Whens, and Hows

52Citations
N/AReaders
Get full text

Vitamin D and Calcium in Osteoporosis, and the Role of Bone Turnover Markers: A Narrative Review of Recent Data from RCTs

32Citations
N/AReaders
Get full text

Rapidly Increasing Serum 25(OH)D Boosts the Immune System, against Infections—Sepsis and COVID-19

28Citations
N/AReaders
Get full text

Register to see more suggestions

Mendeley helps you to discover research relevant for your work.

Already have an account?

Cite

CITATION STYLE

APA

El Sabeh, M., Ghanem, P., Al-Shaar, L., Rahme, M., Baddoura, R., Halaby, G., … El-Hajj Fuleihan, G. (2021). Total, Bioavailable, and Free 25(OH)D Relationship with Indices of Bone Health in Elderly: A Randomized Controlled Trial. Journal of Clinical Endocrinology and Metabolism, 106(2), E990–E1001. https://doi.org/10.1210/clinem/dgaa780

Readers' Seniority

Tooltip

PhD / Post grad / Masters / Doc 5

38%

Researcher 5

38%

Professor / Associate Prof. 2

15%

Lecturer / Post doc 1

8%

Readers' Discipline

Tooltip

Medicine and Dentistry 5

45%

Nursing and Health Professions 3

27%

Agricultural and Biological Sciences 2

18%

Psychology 1

9%

Save time finding and organizing research with Mendeley

Sign up for free