Heterogeneous Expression of SDF1 Retains Actively Proliferating Neural Progenitors in the Capillary Compartment of the Niche

Abstract

The vascular compartment of the adult neurogenic niche is a major regulatory hub for neural stem cells. Here, Kokovay and colleagues show that the chemokine SDF1 is expressed by a subset of the blood vessels within the niche associated with proliferating progenitors. Knockdown of the SDF1 receptor leads to aberrant lineage progression.